Antithyroid drugs in pregnancy

Antithyroid drugs during pregnancy

Propylthiouracil is the drug of choice during the first trimester of pregnancy because it causes less severe birth defects than methimazole.

Because there have been rare cases of liver damage in people taking propylthiouracil, some clinicians will suggest switching to methimazole after the first trimester, while others may continue propylthiouracil.

References:
https://www.uptodate.com/contents/antithyroid-drugs-beyond-the-basics
​https://www.medscape.com/viewarticle/891627

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